Abstract #2137

Growth patterns of non-enhancing glioma assessed on DTI-derived isotropic and anisotropic maps are not associated with IDH and 1p19q codeletion status

Renske Gahrmann¹, J.K.H. Spoor², MMJ Wijnenga³, S Leenstra², AJPE Vincent², M de Groot⁴, PJ French³, MJ van den Bent³, and M Smits¹

¹Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Neurosurgery, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³The Brain Tumor Center, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Medical Informatics, Erasmus MC, University Medical Center, Rotterdam, Netherlands

Previous reports show that IDH-mutation status can be determined in glioblastoma using DTI-derived isotropic (p) and anisotropic (q) maps to measure infiltrative growth along white matter tracts by determining the extent or pattern of p/q mismatch: abnormal p overlaps normal q-areas by >0.5cm. We use this method in presumed low-grade (i.e. non-enhancing) gliomas to see if infiltrative growth patterns correlate with IDH-mutation and 1p19q codeletion status, which in turn are correlated with prognosis.

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