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Abstract #2143

Diffusion kurtosis imaging (DKI) can help to differentiate low- and high-grade gliomas in pediatric patients: a prospective single centre experience with the simultaneous multislice (SMS) technique

Antonio Napolitano1, Ioan Paul Voicu2, Lorenzo Lattavo2, Maria Camilla Rossi Espagnet2, Chiara Carducci2, Angela Mastronuzzi3, Paolo Tomà2, and Giovanna Stefania Colafati2

1Medical Physics Department, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy, 2Imaging Department, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy, 3Department of Pediatric Onco-Hematology and Transfusion Medicine, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy

Pediatric brain glioma is a very devastating brain tumour and the most frequent solid tumour in children. Differentiating low- from high-grade glioma without the use of invasive biopsy is important to optimize patient management strategies yet difficult with imaging alone. Diffusion kurtosis imaging is then an emerging technique that has shown the ability of discriminating grades in adults. We make use of multislice approach to acquire and evaluate kurtosis metrics in brain gliomas and show how estimation of the heterogeneity of the tumour might be indicative of its grade.

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