Abstract #2144

Quantitative proton density values compared to 1H MRSI in areas of contrast enhancement of glioma patients after surgical resection.

Felix Raschke¹, Tim Wesemann², Hannes Wahl², Steffen Appold³, Mechthild Krause^1,3,4,5,6, Jennifer Linn², and Esther G.C. Toost^1,3,4,5,6

¹National Center for Tumor Diseases, partner site Dresden, Germany, Dresden, Germany, ²Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität, Dresden, Germany, ³Department of Radiotherapy and Radiooncology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität, Dresden, Germany, ⁴OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden - Rossendorf, Germany, ⁵Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Rossendorf, Germany, ⁶German Cancer Consortium (DKTK), partner site Dresden, Dresden, Germany

In this study we measured mean proton density (PD) values in MR spectroscopic imaging (MRSI) voxels showing contrast enhancement of glioma patients 30 days ± 12 days after surgical resection. MRSI voxels with (partial) overlap with contrast enhancing areas were manually selected. Mean PD values showed a significant inverse correlation with NAA/Cho indicating that areas with higher PD are more likely to contain residual tumour tissue rather than surgery-related tissue damage. There was, however, no correlation of PD with Cho/Cr, which suggests that quantitative PD values are unable to determine tumour aggressiveness.

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