Abstract #2147

Effects of Glioblastoma (GBM) on quantitative MRI of Contralateral Normal Appearing White Matter

Hatef Mehrabian^1,2, Wilfred W Lam¹, Sten Myrehaug³, Arjun Sahgal³, and Greg J Stanisz¹

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Normal-appearing white matter on the contralateral hemisphere (cNAWM) of glioblastoma (GBM) has been shown with MRS and DTI to be abnormal which might be due to tumor cell infiltration into these distant normal appearing brain structures. Chemical exchange saturation transfer (CEST), quantitative magnetization transfer (qMT) and transverse relaxation time (T₂) are sensitive to changes in tissue microstructure and metabolism. CEST, qMT and T₂-mapping were used to investigate abnormalities in cNAWM. Results demonstrated differences in white mater cellular density (measured with T₂ and qMT) as well as metabolism (measured with CEST) in cNAWM of GBM patients compared to healthy controls.

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