Abstract #2148

Relationship Between Tumor Cellularity and Metabolic Activity in IDH-Mutant Gliomas: A Correlative Study with 2-Hydroxyglutarate MRSI and a Novel Diffusion MRI Method

Ina Ly¹, Ovidiu Andronesi^1,2, Qiuyun Fan^1,2, Barbara Wichtmann³, Aapo Nummenmaa^1,2, Brian Nahed¹, William Curry¹, Daniel Cahill¹, Tracy Batchelor¹, Jayashree Kalpathy-Cramer^1,2, Bruce Rosen^1,2, and Elizabeth Gerstner¹

¹Massachusetts General Hospital, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Anatomic T2/FLAIR sequences are the gold standard in the diagnostic and monitoring process of non-enhancing gliomas but do not provide accurate information about the underlying metabolic activity of the tumor. In this work, we investigated the combined use of 2-hydroxyglutarate (2HG) magnetic resonance spectroscopic imaging (MRSI) and a novel three-compartment diffusion MRI method (Linear Multi-Scale Model) to characterize isocitrate dehydrogenase-mutant gliomas, and found that high 2HG levels correlated with decreased restricted diffusion.

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