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Abstract #2148

Relationship Between Tumor Cellularity and Metabolic Activity in IDH-Mutant Gliomas: A Correlative Study with 2-Hydroxyglutarate MRSI and a Novel Diffusion MRI Method

Ina Ly1, Ovidiu Andronesi1,2, Qiuyun Fan1,2, Barbara Wichtmann3, Aapo Nummenmaa1,2, Brian Nahed1, William Curry1, Daniel Cahill1, Tracy Batchelor1, Jayashree Kalpathy-Cramer1,2, Bruce Rosen1,2, and Elizabeth Gerstner1

1Massachusetts General Hospital, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Anatomic T2/FLAIR sequences are the gold standard in the diagnostic and monitoring process of non-enhancing gliomas but do not provide accurate information about the underlying metabolic activity of the tumor. In this work, we investigated the combined use of 2-hydroxyglutarate (2HG) magnetic resonance spectroscopic imaging (MRSI) and a novel three-compartment diffusion MRI method (Linear Multi-Scale Model) to characterize isocitrate dehydrogenase-mutant gliomas, and found that high 2HG levels correlated with decreased restricted diffusion.

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