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Abstract #2158

Comparing pCASL CBF measurements between 3D-GraSE and 2D-EPI on 1.5T and 3T systems

Koen P.A. Baas1,2, Henri J.M.M. Mutsaerts2,3, Jan Petr3,4, Joost P.A. Kuijer2, and Kim C.C. van de Ven1

1BIU MR, Philips, Best, Netherlands, 2VUmc, Amsterdam, Netherlands, 3Kate Gleason College of Engineering, Rochester Institute of Technology (RIT), Rochester, NY, United States, 4PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

We have compared CBF value agreement in healthy subjects across two readouts, 3D-GraSE and 2D-EPI, and two field strengths, 1.5T and 3T, and investigated with which acquisition parameters we can reach the best agreement. Significantly higher GM CBF was observed with the 2D-EPI readout compared to the 3D-GraSE readout with equivalent acquisition voxel size (p < 0.005 for 1.5T and p < 0.05 for 3T). Better agreement was observed between 3D-GraSE and 2D-EPI on 3T systems when the resolution of the 3D-GraSE readout was increased to match the effective resolution to the 2D-EPI scan (ICC = 0.772 and ICC = 0.932 respectively).

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