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Abstract #2159

Reproducibility and repeatability of 3D-GraSE and 2D-EPI ASL on 1.5T and 3T systems in healthy elderly

Koen P.A. Baas1,2, Henri J.M.M. Mutsaerts2,3, Joost P.A. Kuijer2, and Kim C.C. van de Ven1

1BIU MR, Philips, Best, Netherlands, 2VUmc, Amsterdam, Netherlands, 3Kate Gleason College of Engineering, Rochester Institute of Technology (RIT), Rochester, NY, United States

We present the results of a reproducibility and repeatability study in 34 healthy elderly scanned on 1.5T and 3T systems employing pCASL with a 3D-GraSE and 2D-EPI read-out. Best repeatability and reproducibility were achieved when using 3D-GraSE readout on 3T systems leading to an average repeatability and reproducibility of GM CBF of 2.7% ± 1.8% and 2.9% ± 3.5% respectively. The repeatability and reproducibility of 2D read-out and of comparisons at 1.5T and 1.5T versus 3T were slightly lower. These results imply that 3D-GraSE pCASL at 3T should be preferred in multi-center trials as well as for clinical imaging.

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