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Abstract #2182

Incorporating Bolus Arrival Time Offset into Fast Linear Analysis Could Shorten Acquisition Times for DCE-MRI

Sharon Peled1, Ron Kikinis1, Fiona Fennessy1, and Andrey Fedorov1

1Brigham and Women's Hospital, Boston, MA, United States

Linearization of the Kety/Tofts model for DCE analysis drastically shortens computation time. We show that addition of bolus arrival time (BAT) compensation to the linearized analysis could also allow quicker acquisition times. With BAT inclusion, 3 minute sequences yield equivalent parameter estimation accuracy to 5 minute sequences without BAT compensation. The combination of shorter acquisition and real-time analysis would reduce the general time burden of DCE, which has potential implications for increased patient turnaround, and making DCE more acceptable as a tool, for example in evaluating response to therapy or in image guided therapy.

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