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Abstract #2184

Measuring transient T2* changes in vivo to validate Dynamic Distributed Spirals, a novel DSC-perfusion method

Dallas C Turley1 and James G Pipe2

1Department of Radiology, University of Chicago, Chicago, IL, United States, 2MR Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States

Validating new contrast-enhances sequences is problematic, as risks associated with gadolinium contrast agents generally preclude testing in healthy volunteers. The Dynamic Distributed Spirals trajectory (DDS) is a promising new dynamic susceptibility-contrast (DSC)-perfusion method. In this work, we show that DDS is capable of measuring the transient T2* changes induced by breathholding which are much lower in magnitude than the susceptibility changes induced by contrast agent transit in conventional DSC-perfusion experiments.

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