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Abstract #2185

Diffusion dependency of oxygenation measurements obtained with Vessel Architectural Imaging

Ingrid Digernes1, Atle Bjørnerud1,2, Grete Løvland1, Einar Vik-Mo3, Torstein Meling3,4, and Kyrre Eeg Emblem1

1Oslo University Hospital, Oslo, Norway, 2Department of Physics, University of Oslo, Oslo, Norway, 3Department of Neurosurgery, Oslo University Hospital, Oslo, Norway, 4Institute of Clinical Medicine, University of Oslo, Oslo, Norway

With the dual echo DSC-based technique Vessel Architectural Imaging (VAI), measurement of oxygenation level (∆SO2) can be obtained. However, how the ∆SO2-parameter is influenced by diffusion have previously not been investigated. Based on simulations, we show that the measured ∆SO2 obtained from VAI have a diffusion dependency proportional to 1/ √D. ADC-maps from 10 glioblastoma patients were used to display the range correction factors in white matter and tumor regions. In conclusion, the diffusion dependency should be corrected for to obtain more accurate measurements of ∆SO2, and may be especially relevant for brain diseases with aberrant diffusion characteristics.

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