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Abstract #2190

COSMOS for Estimating Variation in Single Orientation Quantitative Susceptibility Mapping of the Brain: An Ultra High Field Study

Jon O Cleary1, Hongfu Sun2, Rebecca Glarin1, Peter Yoo1, Bradford A Moffat1, Roger J Ordidge1, and Scott C Kolbe1

1Melbourne Brain Centre Imaging Unit, Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia, 2Department of Radiology, University of Calgary, Calgary, AB, Canada

The purpose of this study was to use high resolution Calculation of susceptibility through Multiple Orientation Sampling (COSMOS) reconstructed QSM (QSMc) as a gold standard to estimate the variation, distribution and magnitude of a single orientation QSM reconstruction pipeline. QSMc processing is an emerging technique for overcoming artefacts characteristic of single orientation QSM (QSMs). However it requires at least 4 fold increases in image acquisition times or reductions in resolution and SNR. We sought to produce high resolution QSMc reference datasets from healthy subjects to quantify the differences from QSMs values across a variety of cortical and subcortical brain regions.

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