The purpose of this study was to use high resolution Calculation of susceptibility through Multiple Orientation Sampling (COSMOS) reconstructed QSM (QSMc) as a gold standard to estimate the variation, distribution and magnitude of a single orientation QSM reconstruction pipeline. QSMc processing is an emerging technique for overcoming artefacts characteristic of single orientation QSM (QSMs). However it requires at least 4 fold increases in image acquisition times or reductions in resolution and SNR. We sought to produce high resolution QSMc reference datasets from healthy subjects to quantify the differences from QSMs values across a variety of cortical and subcortical brain regions.
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