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Abstract #2191

Evaluating the Precision of Multi-Echo Combination Methods for Susceptibility Mapping by Analysing the Propagation of Single-Echo Phase Noise into Multi-Echo Field and Susceptibility Maps

Emma Biondetti1, Anita Karsa1, David L Thomas2,3, and Karin Shmueli1

1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 3Leonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, United Kingdom

In Susceptibility Mapping (SM) using multi-echo acquisitions, noise propagates from the single-echo phase images into the field map in a manner dependent on the method used for multi-echo combination. Field noise then propagates into the susceptibility map, determining the precision of the measured susceptibility. Here, we characterised the propagation of single-echo phase noise into both the combined field and susceptibility maps using three methods for multi-echo combination: fitting, averaging and echo time-weighted averaging. We calculated susceptibility noise maps for both simulated and acquired data, showing that, when choosing a pipeline for multi-echo SM, it is important to consider its precision.

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