Abstract #2211

Improved depiction of subthalamic nucleus and globus pallidus internus with optimized high-resolution quantitative susceptibility mapping at 7 Tesla

Fei Cong^1,2, Yelong Shen^3,4, Bo Wang¹, Jing An⁵, Zihao Zhang¹, Zhentao Zuo¹, Yan Zhuo¹, and Lirong Yan³

¹State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴Shandong Medical Imaging Research Institute, School of Medicine, Shandong University, Jinan, China, ⁵Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Quantitative susceptibility mapping (QSM) shows a potential to image subthalamic nucleus (STN) and globus pallidus internus (GPi). However, the image quality of QSM is dependent on the selection of regularization parameter during reconstruction. Here we proposed an approach to determine the optimal regularization parameter for imaging the sub-cortical nuclei at different spatial resolution and field strengths. Optimized QSM images were further compared with the other susceptibility weighted images for visualization of STN and GPi at 3T and 7T. Our results suggest that optimized 7T QSM with spatial resolution of 0.35x0.35x1.0mm³ provides better delineation of STN and GPi.

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