Abstract #2210

Measurement of Iron Concentration in Deep Gray Matter Nuclei over the Lifespan Using Quantitative Susceptibility Mapping

Gaiying Li¹, Rui Tong¹, Binshi Bo¹, Miao Zhang¹, Yu Zhao¹, Tian Liu², Yasong Du³, Xu Yan⁴, Yi Wang^1,2, and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shangha, China, ²Department of Radiology, Weill Medical College of Cornell University, New York, New York, NY, United States, ³Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Histological in vitro analysis has demonstrated that iron accumulation rates in various gray matter nuclei are different throughout an individual’s lifetime. QSM provides excellent contrast of iron-rich deep nuclei to quantify iron in the brains. In this study, we investigated the linear and nonlinear correlation of magnetic susceptibility in the deep gray matter nuclei as a function of ageing using QSM. Compared with the published studies, the nonlinear analysis results showed the differential developmental trajectories of magnetic susceptibility in the deep gray matter nuclei over the lifespan.

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