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Abstract #2210

Measurement of Iron Concentration in Deep Gray Matter Nuclei over the Lifespan Using Quantitative Susceptibility Mapping

Gaiying Li1, Rui Tong1, Binshi Bo1, Miao Zhang1, Yu Zhao1, Tian Liu2, Yasong Du3, Xu Yan4, Yi Wang1,2, and Jianqi Li1

1Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shangha, China, 2Department of Radiology, Weill Medical College of Cornell University, New York, New York, NY, United States, 3Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Histological in vitro analysis has demonstrated that iron accumulation rates in various gray matter nuclei are different throughout an individual’s lifetime. QSM provides excellent contrast of iron-rich deep nuclei to quantify iron in the brains. In this study, we investigated the linear and nonlinear correlation of magnetic susceptibility in the deep gray matter nuclei as a function of ageing using QSM. Compared with the published studies, the nonlinear analysis results showed the differential developmental trajectories of magnetic susceptibility in the deep gray matter nuclei over the lifespan.

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