Abstract #2221

Validation of Quantitative Susceptibility Mapping of the Liver at 1.5T and 3.0T using SQUID-Based Liver Susceptometry as the Reference

Ruiyang Zhao^1,2, Valentina Taviani ³, Shreyas Vasanawala⁴, Scott B. Reeder^1,2,5,6,7, and Diego Hernando^1,2

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, ⁴Radiology, Stanford University, Palo Alto, CA, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Accurate quantification of liver iron concentration (LIC) is needed for the assessment of iron overload. Quantification of magnetic susceptibility may enable accurate and reproducible estimation of LIC. SQUID-based biomagnetic liver susceptometry (BLS) is used clinically to measure magnetic susceptibility, but has very limited availability. MRI-based Quantitative Susceptibility Mapping (QSM) may enable liver susceptometry with much broader availability. However, the accuracy of QSM-BLS across field strengths remains unknown. In this abstract, we observed strong correlation (r²=0.90) between QSM-BLS (at both 1.5T and 3.0T) with SQUID-BLS in patients with known or suspected iron overload.

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