Meeting Banner
Abstract #2222

A novel normalization to correct APT-CEST in the presence of fat

Ferdinand Zimmermann1, Andreas Korzowski1, Patrick Schuenke1, Johannes Breitling1, Mark Ladd1, Peter Bachert1, and Steffen Goerke1

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

Chemical Exchange Saturation Transfer (CEST) MRI in the human breast is affected by the fat content in the fibro glandular tissue. Although the spectral region of the amide proton transfer (APT) signal does not overlay with fat resonances, the fat signal leads to an incorrect normalization of the Z-spectrum and therefore to misleading CEST effects. We propose a novel method yielding a corrected normalization without the need for application of fat saturation schemes, thus enabling APT-CEST imaging corrected for fat signal contribution. Transfer of the gained insights to realize correct APT-CEST in the human breast at 7T is currently under investigation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here