Abstract #2223

Rapid and Quantitative Chemical Exchange Saturation Transfer (CEST) Imaging of In Vivo Rat Brain with Magnetic Resonance Fingerprinting (MRF)

Ouri Cohen^1,2, Shuning Huang³, Michael T. McMahon^4,5, Matthew S. Rosen^1,2, and Christian T. Farrar¹

¹Martinos Center for Biomedical Imaging, Deprtment of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Physics Department, Harvard University, Cambridge, MA, United States, ³Department of Biomedical Engineering, Texas A&M University, College Station, TX, United States, ⁴Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

CEST MRI suffers from several limitations including long image acquisition times and the qualitative nature of the CEST contrast. Clinical translation of CEST MRI would benefit greatly from the development of quantitative and rapid CEST methods. Here we build on the recently developed Magnetic Resonance Fingerprinting (MRF) technique and report the use of a fast CEST fingerprinting method for generating quantitative exchange rate and exchangeable proton concentration maps of L-Arginine phantoms and in vivo rat brain tissue.

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