Meeting Banner
Abstract #2227

Mapping elevated lactate levels after ischemic stroke using PROBE CEST/NOE: a feasibility study in patients at 3T

Tobias Lenich1, André Pampel1, Toralf Mildner1, Ralf Mekle2, Ramanan Ganeshan2, Jochen B. Fiebach2, and Harald E. Möller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Center for Stroke Research Berlin (CSB), Charité – Universitätsmedizin Berlin, Berlin, Germany

In ischemic stroke, anaerobic glycolysis leads to a local increase in lactate concentration. Such elevated levels of lactate can be detected via CEST/NOE. In vivo, several broad tissue contributions as well as metabolites lead to a complex intermingled baseline in Z-spectra. With PROBE, such effects are compensated based on healthy tissue, and a flat baseline is achieved. Stroke affected areas can hence be identified in direct contrast to healthy tissue. Lactate contributions to the Z-spectrum became distinctively observable. The feasibility was demonstrated in-vivo for thalamic stroke in a clinical setting at 3T.

This abstract and the presentation materials are available to members only; a login is required.

Join Here