Abstract #2228

Dependence of rNOE-CEST signals on molecular weight

Steffen Goerke¹, Johannes Breitling¹, Karel D Klika², Mark E Ladd¹, and Peter Bachert¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, rNOE-CEST signals of proteins have been demonstrated to depend on molecular weight. This finding can explain the observed intensity decrease of aliphatic rNOE-CEST signals in tumors in comparison to healthy tissue.

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