Abstract #2233

Optimization of OH-CEST contrast at 3T for clinical application of glucoCEST MRI

Chirayu Gandhi¹, Dario Longo², Annasofia Anemone³, Kai Herz¹, Anagha Deshmane¹, Tobias Lindig⁴, Benjamin Bender⁴, Silvio Aime³, Klaus Scheffler¹, and Moritz Zaiss¹

¹High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche (CNR), Torino, Italy, ³Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Torino, Italy, ⁴Diagnostic & Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany

A 3D snapshot CEST sequence is optimized for contrast originating from hydroxyl groups of glucose molecules. Multi-B1-multi-pH measurements allow fitting of exchange rates of four glucose hydroxyl groups, which are then used to optimize pre-saturation parameters in simulation. The optimal protocol gave highly reproducible signals in 6 healthy volunteers, and showed no contrast when tested in a brain tumor patient. This protocol provides a robust baseline for glucose injection studies.

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