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Abstract #2233

Optimization of OH-CEST contrast at 3T for clinical application of glucoCEST MRI

Chirayu Gandhi1, Dario Longo2, Annasofia Anemone3, Kai Herz1, Anagha Deshmane1, Tobias Lindig4, Benjamin Bender4, Silvio Aime3, Klaus Scheffler1, and Moritz Zaiss1

1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche (CNR), Torino, Italy, 3Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Torino, Italy, 4Diagnostic & Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany

A 3D snapshot CEST sequence is optimized for contrast originating from hydroxyl groups of glucose molecules. Multi-B1-multi-pH measurements allow fitting of exchange rates of four glucose hydroxyl groups, which are then used to optimize pre-saturation parameters in simulation. The optimal protocol gave highly reproducible signals in 6 healthy volunteers, and showed no contrast when tested in a brain tumor patient. This protocol provides a robust baseline for glucose injection studies.

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