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Abstract #2242

Implications of tissue compartmentalisation on APT MRI

Kevin J Ray1,2, Michael A Chappell3, and Nicola R Sibson2

1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

Amide proton transfer (APT) MRI is assumed to report on the intracellular environment. However, no attempt has been made to verify this assumption, or examine the extent to which tissue compartmentalisation contaminates measurements of biophysical parameters (e.g. protein concentration, pH) from APT MRI data. In this simulation study, we show that measurement of biophysical parameters by APT MRI is influenced by tissue compartmentalisation when the transcytolemmal exchange rate is slow (<2Hz). Since recent studies have reported transcytolemmal exchange to be in such a regime, it may be possible to separate intra- and extracellular APT signals.

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