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Abstract #2243

A Phantom Investigation into the Biosynthesis Pathway of Serotonin Using CEST

Ryan T. Oglesby1,2, Wilfred W. Lam2, and Greg J. Stanisz1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

The four metabolites involved in the biosynthesis pathway of serotonin were scanned at 7T using CEST MRI in order to characterize the Z-spectrum of each. It was found that each metabolite was distinguishable from one another according to their peak location and amplitude at physiological temperature and pH within experimental uncertainty. Using a Bloch-McConnell exchange model, each metabolite was fitted for T1, T2, peak location Δ0C, exchange rate RC, and pool size M0. The in vitro CEST MRI data acquired during this investigation may increase the specificity of in vivo Z-spectrum interpretation during an investigation focused on detecting serotonin.

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