Abstract #2243

A Phantom Investigation into the Biosynthesis Pathway of Serotonin Using CEST

Ryan T. Oglesby^1,2, Wilfred W. Lam², and Greg J. Stanisz^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

The four metabolites involved in the biosynthesis pathway of serotonin were scanned at 7T using CEST MRI in order to characterize the Z-spectrum of each. It was found that each metabolite was distinguishable from one another according to their peak location and amplitude at physiological temperature and pH within experimental uncertainty. Using a Bloch-McConnell exchange model, each metabolite was fitted for T₁, T₂, peak location Δ_0C, exchange rate R_C, and pool size M₀. The in vitro CEST MRI data acquired during this investigation may increase the specificity of in vivo Z-spectrum interpretation during an investigation focused on detecting serotonin.

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