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Abstract #2248

High-resolution total Creatine mapping of the mouse brain at 11.7T using CEST

Lin Chen1,2,3, Zhiliang Wei1,2, Xiang Xu1,2, Yuguo Li1,2, Shuhui Cai3, Guanshu Liu1,2, Hanzhang Lu1,2, Peter B. Barker1,2, Robert G. Weiss1, Peter C.M. van Zijl1,2, and Jiadi Xu1,2

1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Electronic Science, Xiamen University, Xiamen, China

A combined polynomial and Lorentzian Fitting (PLOF) scheme was developed to map total creatine (tCr) signal using a CW-CEST sequence under short saturation time situation. At 11.7T, the guanidinium proton signals of tCr and tissue proteins are not coalesced with the water signal and the line-shape fitting procedure can correct the direct saturation and magnetization transfer contrast introduced spill-over effects, allowing the guanidinium CEST signal to be extracted and subsequently quantified. A series of Cr phantom and mouse brain studies with different saturation times and powers were carried out to determine the optimal parameters for protein-signal corrected creatine CEST quantification.

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