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Abstract #2249

Low power Z-spectrum analysis for isolated NOE and amide CEST-MRI at 3T with comparison to 9.4T

Anagha Deshmane1, Moritz Zaiss1, Benjamin Bender2, Tobias Lindig2, Johannes Windschuh3, Kai Herz1, and Klaus Scheffler1

1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Diagnostic & Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany, 3Center for Biomedical Imaging, New York University Langone Health, New York, NY, United States

A snapCEST sequence was optimized for imaging of protein CEST effects at 3T with low saturation power. Full Z-spectrum sampling allows Lorentzian fitting of amide, NOE, semisolid MT, and water pools. Validation against data acquired at 9.4T demonstrates effective labeling of selective amide and NOE CEST effects at 3T. Data acquired in a brain tumor patients demonstrates clinical feasibility.

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