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Abstract #2257

Robust chemical exchange spin-lock (CESL) using adiabatic pulses

Baiyan Jiang1, Jing Yuan2, Queenie Chan3, Yi-Xiang Wang1, and Weitian Chen1

1Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, 2Medical physics and research department, Hong Kong, Hong Kong, 3Philips Healthcare, Hong Kong, Hong Kong

Chemical exchange spin-lock (CESL) is a recently reported technology for probing metabolites which have intermediate to fast chemical exchange with bulk water. However, the conventional CESL is susceptible to B1 radiofrequency (RF) and B0 field inhomogeneity. The presence of these system imperfections leads to signal distortions and errors in contrast map. In this work, we report an approach to address this problem. We used simulation and in vivo experiments to demonstrate our proposed method.

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