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Abstract #2259

Lipid nanocapsules for tissue oxygenation determination using MRI

Janske Nel1,2, Florence FRANCONI3, Nicolas JOUDIOU 2, Bernard GALLEZ2, and Laurent LEMAIRE1

1Micro et Nanomedecines translationnelles, MINT, Université d'Angers, Angers, France, 2Biomedical Magnetic Resonance Unit (REMA), Université catholique de Louvain, Woluwe-Saint-Lambert, Belgium, 3PRISM, Université d'Angers, Angers, France

To determine tissue pO2, lipid nanocapsules (LNCs) were used in conjunction with the rapid mapping of changes in tissue oxygenation, based on the higher solubility of O2 in lipids than in water, (MOBILE) MR sequence. LNCs were injected into the femoral muscle (n = 5) of C3H mice and T1 relaxation was measured whilst the animal was breathing air or carbogen (95 % O2, 5 % CO2) gas . In all explored mice a shortening in T1 relaxation was observed following the carbogen challenge, and T1 relaxation maps were produced indicating a response of the LNCs to the tissue O2 environment.

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