Abstract #2271

Towards Quantifying pO2 via 1H Longitudinal Relaxation of Water: Quantifying the Confounds

Kelsey Meinerz¹, Scott C. Beeman², James D. Quirk², Joel R. Garbow^2,3, and Joseph J.H. Ackerman^2,3,4,5

¹Physics, Washington University in St Louis, St Louis, MO, United States, ²Radiology, Washington University in St Louis, Saint Louis, MO, United States, ³Siteman Cancer Center, Washington University in St Louis, Saint Louis, MO, United States, ⁴Internal Medicine, Washington University in St Louis, Saint Louis, MO, United States, ⁵Chemistry, Washington University in St Louis, Saint Louis, MO, United States

Crosslinked bovine serum albumin phantoms are used as tissue surrogates/mimics to investigate the physiologic confounds to R₁-based tissue-O₂ quantification under precise, laboratory controlled conditions. The relaxation-rate constants for both the rapidly relaxing and the slowly relaxing populations are affected by changes in temperature, pH, and protein concentration.

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