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Abstract #2272

Increased CEST specificity for amide and fast exchanging amine protons using exchange-dependent relaxation rate

Xiao-Yong Zhang1, Feng Wang2, Junzhong Xu2, Daniel Gochberg2, John Gore2, and Zhongliang Zu2

1Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

It is challenging to remove overlapping chemical exchange saturation transfer (CEST) signals from nearby exchanging sites. Our previous study showed that the contributions of fast exchanging amines to CEST signals at 3 ppm induce a broad spectral region that overlaps with the amide proton transfer (APT) spectrum centered around 3.5 ppm. In this work, we apply an exchange-dependent relaxation rate (Rex) for quantifying CEST effects to increased CEST specificity for amide and fast exchanging amine protons. Our results demonstrate that Rex reduces the influences of overlapping CEST signals for APT imaging, and thus can significantly enhances the CEST detection specificity.

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