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Abstract #2273

MR Elastography of the brain: Comparison between anisotropic and isotropic stiffness with age

Prateek Kalra1, Brian Raterman1, Xiaokui Mo2, and Arunark Kolipaka1

1Radiology, Ohio State University Wexner Medical Center, Columbus, OH, United States, 2Center for Biostatistics, Ohio State University Wexner Medical Center, Columbus, OH, United States

Noninvasive measurement of mechanical properties of brain tissue using Magnetic Resonance Elastography has been a promising method for investigating neurological disorders such as multiple sclerosis, hydrocephalus and Alzheimer’s. However, due to regional and directional dependency of brain stiffness, estimating anisotropic stiffness is important. Previous studies have investigated anisotropic and isotropic stiffness separately but none of them investigated the two together. Objective of this study is to investigate both isotropic and anisotropic stiffness together and independently compare with age and with each other. Results demonstrated a significant decrease in isotropic and anisotropic stiffness with age in some regions of the brain.

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