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Abstract #2275

Chemical Exchange Saturation Transfer (CEST) MRI of glucosamine at 3T

Michal Rivlin1, Daniel Barazany2, and Gil Navon1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 2Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel

In our previous work using preclinical 7T MRI scanner we have shown that tumors in mice can be imaged using CEST-MRI of glucosamine. Moving toward clinical application, considering the excellent safety profile of glucosamine, we tested the CEST-MRI of glucosamine on a 3T clinical scanner. Here we report significant CEST MRI signal up to ~3.5 ppm from the water signal corresponding to the exchangeable protons of the glucosamine hydroxyls and amine residues. Thus, CEST MRI using glucosamine has the potential to report on the activity of tumor metabolism, noninvasively by using MRI.

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