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Abstract #2276

Live monitoring of red and yellow bone marrow in long bones of the mouse at 9.4T

Nicolas Kunz1, Josefine Tratwal2, and Olaia Naveiras2,3

1AIT, CIBM, Lasaunne, Switzerland, 2Laboratory of Regenerative Hematopoiesis, EPFL, Lausanne, Switzerland, 3Department of Oncology, CHUV, Lausanne, Switzerland

When hematopoiesis is compromised, as after lethal irradiation, the red BM is rapidly infiltrated by fat, then slowly recovers hematopoietic function following BM transplantation. Monitoring this red-to-yellow-to-red BM transition non-invasively using a tree point Dixon technique would provide important information on the reconstitution of the hematopoietic system that precedes blood formation as measured by bleeding, and thus be extremely useful in experimental hematology.

In this preliminary study we investigate the feasibility to track differences in bone marrow adiposity in the C57B6 mouse femur and tibia post-irradiation by monitoring the fat content.

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