Abstract #2289

Implementation and validation of delta relaxation enhanced MRI at 3T: A system for quadrupole enhanced relaxation imaging

Markus Bödenler¹, Martina Basini², Maria Francesca Casula³, Evrim Umut⁴, Danuta Kruk⁴, and Hermann Scharfetter¹

¹Graz University of Technology, Graz, Austria, ²Università degli Studi di Milano, Milano, Italy, ³Università di Cagliari, Monserrato, Italy, ⁴University of Warmia and Mazury, Olsztyn, Poland

The frequency-selective nature of quadrupolar relaxation enhancement offers a high potential for designing smart molecular probes for the usage as novel MRI contrast agents by cycling the main magnetic field. Their validation and application requires a fast field-cycling MRI system. In this work, we present the first implementation and validation of such a system at the clinical field strength of 3T. The complete FFC-MRI setup was successfully validated by R₁ dispersion imaging with dispersive iron oxide magnetic nanoparticles, thus providing a ready-to-use hardware setup for the future investigation of new compounds.

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