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Abstract #2289

Implementation and validation of delta relaxation enhanced MRI at 3T: A system for quadrupole enhanced relaxation imaging

Markus Bödenler1, Martina Basini2, Maria Francesca Casula3, Evrim Umut4, Danuta Kruk4, and Hermann Scharfetter1

1Graz University of Technology, Graz, Austria, 2Università degli Studi di Milano, Milano, Italy, 3Università di Cagliari, Monserrato, Italy, 4University of Warmia and Mazury, Olsztyn, Poland

The frequency-selective nature of quadrupolar relaxation enhancement offers a high potential for designing smart molecular probes for the usage as novel MRI contrast agents by cycling the main magnetic field. Their validation and application requires a fast field-cycling MRI system. In this work, we present the first implementation and validation of such a system at the clinical field strength of 3T. The complete FFC-MRI setup was successfully validated by R1 dispersion imaging with dispersive iron oxide magnetic nanoparticles, thus providing a ready-to-use hardware setup for the future investigation of new compounds.

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