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Abstract #2290

Quadrupolar relaxation enhancement in selected Bismuth-Aryl compounds: Promising precursors for novel T1 MRI contrast agents

Hermann Scharfetter1, Christian Gösweiner1, Evrim Umut2, Carina Sampl3, Roland Fischer3, Stefan Spirk4, Andreas Petrovic1, and Danuta Kruk2

1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Faculty of Mathematics and Computer Science, Universtiy of Warmia and Mazury, Olsztyn, Poland, 3Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria, 4Institute of Paper, Pulp and Fibre Technology, Graz University of Technology, Graz, Austria

209Bi-aryl compounds have the potential for designing novel class of smart MRI T1 contrast agents which are sensitive to the chemical environment and the B0 field. We have confirmed quadrupolar relaxation enhancement (QRE) of protons as the underlying mechanism in two solid organobismuth-compounds in the B0 range 0.5 – 3T. We also show first QRE peaks of solvent protons in a solution of Tris-(2-orthomethoxy-Phenyl)Bismuthane in tetrahydrofurane. This very important first step yields two promising candidates for the development of QRE-based CAs and opens the way for the second step, i.e. grafting them onto water-soluble nanoparticles for optimizing the relaxivity.

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