Abstract #2290

Quadrupolar relaxation enhancement in selected Bismuth-Aryl compounds: Promising precursors for novel T1 MRI contrast agents

Hermann Scharfetter¹, Christian Gösweiner¹, Evrim Umut², Carina Sampl³, Roland Fischer³, Stefan Spirk⁴, Andreas Petrovic¹, and Danuta Kruk²

¹Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ²Faculty of Mathematics and Computer Science, Universtiy of Warmia and Mazury, Olsztyn, Poland, ³Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria, ⁴Institute of Paper, Pulp and Fibre Technology, Graz University of Technology, Graz, Austria

²⁰⁹Bi-aryl compounds have the potential for designing novel class of smart MRI T₁ contrast agents which are sensitive to the chemical environment and the B₀ field. We have confirmed quadrupolar relaxation enhancement (QRE) of protons as the underlying mechanism in two solid organobismuth-compounds in the B₀ range 0.5 – 3T. We also show first QRE peaks of solvent protons in a solution of Tris-(2-orthomethoxy-Phenyl)Bismuthane in tetrahydrofurane. This very important first step yields two promising candidates for the development of QRE-based CAs and opens the way for the second step, i.e. grafting them onto water-soluble nanoparticles for optimizing the relaxivity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.