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Abstract #2300

Sex differences in resting-state cerebral activity alterations in Internet gaming disorder

Yawen Sun1, Yan Zhou1, Yao Wang1, Xu Han1, Weina Ding1, Yong Zhang2, Jianxun Qu2, and Jianrong Xu1

1Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Ge Applied Science Laboratory, GE Healthcare, Shanghai, China

The purpose of this study was to explore the sex-specific neuroimaging differences involved in IGD. Thirty IGDm, 23 IGDf, 30 HCm and 22 HCf underwent rs-fMRI. ALFF and seed-based FC maps were constructed. A two-factor ANCOVA model was specified using SPM8, with sex and diagnosis as the between-subject factors. When interaction effects occurred, post-hoc pair-wise comparisons were performed using two-sample t-tests within the interaction masks. IGDm and IGDf exhibited different regional and network-level functional changes. Lower ALFF values in the orbit part of SFG showed higher impulsivity in IGDm. The results may lead to improved sex-specific treatment and prevention strategies .

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