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Abstract #2301

Human whole-brain sub-millimeter cerebral blood flow map using 7T ASL

Dimo Ivanov1, Sriranga Kashyap1, Roy AM Haast1, Shanice Janssens1, Laurentius Huber2, Benedikt A Poser1, and Kâmil Uludağ1

1Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2SFIM, NIMH, Bethesda, MD, United States

Arterial spin labeling (ASL) offers non-invasive cerebral blood flow (CBF) measurements, but typically suffers from low signal-to-noise ratio, limiting the achievable spatial resolution. In this work, we employ 3D EPI ASL at 7T, partially-overlapping acquisition of multiple slabs and across-session averaging to achieve a high-quality whole-brain 0.7 mm3 isotropic resolution CBF map from a healthy volunteer. The dataset presents the highest spatial resolution CBF map in humans so far, and a unique opportunity to investigate the cortical distribution of baseline CBF across and within brain areas, including providing a physiological basis for the interpretation of laminar and columnar fMRI.

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