Understanding of functional brain responses yields insights into satiety signaling, nutrient sensing, energy seeking and feeding behavior. The current aim was to determine normal whole brain functional responses to the ingestion of glucose in healthy normal weight subjects using BOLD signal, network connectivity and Eigen vector centrality functional MRI analysis approaches. Our results show that ingestion of glucose in a fasted state leads to deactivation and decreased connectivity, which can be associated with satiation and reward effects in the brain and a decrease in energy seeking. In contrast, drinking plain water leads to activation and increased centrality and connectivity.
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