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Abstract #2304

Anesthesia affects connectivity of default-mode sub-networks in the rat in a time-dependent and region-dependent manner

Punitkumar Makani1, Rolf Gruetter2, and Ileana Ozana Jelescu2

1University of Tübingen, Tübingen, Germany, 2Centre d'Imagerie Biomédicale, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Anesthetic agents affect brain connectivity and/or neurovascular coupling, with confounding effects on BOLD resting-state fMRI. To date, the most widespread anesthesia protocol for fMRI in rats consists in isoflurane induction followed by medetomidine sedation. We report that, using this protocol, connectivity of default-mode sub-networks is affected in a time-dependent and region-dependent manner, with modules such as hippocampus becoming detectable as late as two hours into sedation. These spatio-temporal features have significant implications for the interpretation and comparison of resting-state studies in the rat, and of the default-mode network connectivity in particular.

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