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Abstract #2305

Cortical propagation of slow oscillation-associated traveling waves resolved by fast line scanning in brain-state-informed BOLD fMRI

Andrea Kronfeld1, Felipe Aedo-Jury1, Lara Hamzehpour1, and Albrecht Stroh1

1Institute of Microanatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

Cortical activity patterns – both spontaneous and stimulus-evoked – are significantly impacted by the respective functional brain state. Here, we explored activity patterns in two brain states: persistent state, maintained by sedation, and slow wave state, dominated by slow-oscillation-associated waves, maintained by rather deep anesthesia. Upon visual stimulation, we found localized activation of the visual cortex only in persistent state, whereas in slow wave state, large areas of the cortex are recruited. By applying fast line scanning methods, we could for the first time resolve a propagation of slow waves by fMRI, presumably evoked by visual stimulation.

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