Abstract #2316

Force-related BOLD effects during naturalistic and symbolic effort observation

Letizia Casiraghi^1,2, Adnan Alahmadi ^3,4, Anita Monteverdi¹, Fulvia Palesi^2,5, Gloria Castellazzi^2,6, Giovanni Savini^2,7, Karl Friston⁸, Claudia Angela Gandini Wheeler-Kingshott^1,4,9, and Egidio D'Angelo ^1,2

¹Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ²Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, ³Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia, ⁴Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, ⁵Brain Connectivity Center, University of Pavia, Pavia, Italy, ⁶Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, ⁷Department of Physics, University of Milan, Milan, Italy, ⁸University College London (UCL), London, United Kingdom, ⁹Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

In this pilot study, we used a 3-condition fMRI squeezeball paradigm to study the non-linear BOLD response to varying grip force (GF) during action execution (AE, subjects performed the task), action observation (AO, subjects watched a video of the task) and AO with visual cue (AOvc). fMRI activity patterns in brain circuits controlling AE, AO and AOvc account for different GF applied to an object or perceived from others’ action. AO and AOvc calls different processing depending on the presence or the absence of the visual cue indicating specific regions and BOLD-GF relations for the effort perception.

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