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Abstract #2315

Functional connectivity and dynamic change of rat brain resting-state networks under morphine-induced condition

Wei Zhu1, Hannes M. Wiesner1, Xiao-Hong Zhu1, Yi Zhang1, Nanyin Zhang2, Yunchong Ma2, and Wei Chen1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, MINNEAPOLIS, MN, United States, 2Department of Biomedical Engineering, Penn State University, State College, PA, United States

Resting-state fMRI (rs-fMRI) in animal is essential for studying neural networks and translational research. However, animal motion poses a major obstacle for performing rs-fMRI, and it is commonly requires anesthesia that could suppress and alter the resting-state networks (RSNs). In this work, we investigated the rat RSNs under morphine condition, and the differentiation and transition of RSNs when animal conditions were changing from isoflurane to morphine. We found that the number of RSNs was significantly increased from deep anesthesia to morphine-induced condition; the RSNs became highly specific to brain functions; and thus, RSN mapping became more reliable.

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