Abstract #2330

ICA cleanup for improved SNR in arterial spin labeling perfusion MRI

Xuetao Hao¹, Jan Petr², Aart JJ Nederveen³, John Wood⁴, Danny JJ Wang¹, Henk-Jan Mutsaerts³, and Kay Jann¹

¹USC Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine at USC, University of Southern California, Los Angeles, CA, United States, ²Institute of Radiopharmaceutical cancer research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ³Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, ⁴Cardiology and Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States

We evaluate the use of Independent Component Analysis (ICA) to separate physiological and other noise from Arterial Spin Labeling (ASL) perfusion MRI as has been shown for BOLD fMRI. We show that this approach improves tSNR and cerebral blood flow (CBF) quantification in a cohort of healthy young controls and a group of children with sickle cell disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.