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Abstract #2331

Functional MRI of the Letter Cancellation Test

Luke Chung1, Nathan Churchill2, Megan Hird2, Tahira Tasneem2, Fred Tam1, Simon Graham1,3, and Tom Schweizer2

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2St. Michael's Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

Letter cancellation test (LCT) variants are widely used pen-and-paper assessment tools in clinical and experimental psychology, but brain regions that mediate LCT performance are not well understood. An fMRI study involving elderly healthy volunteers was conducted to establish the neural correlates of the LCT using a highly novel fMRI-compatible tablet system that enables investigation of drawing behavior. The resultant brain activation highlighted parietal and frontal regions, consistent with existing fMRI literature on visual attention. This is the first fMRI study of the LCT and the results have relevance for future clinically-oriented fMRI studies of this test.

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