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Abstract #2332

Cardiac-Gated 4-Echo Spiral Sequence for ME-ICA Denoising of fMRI Data

Patricia Lan1, Christine Law2, and Gary Glover2

1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

One challenge in fMRI is separating neuronal from artifactual signal fluctuations. Recent developments in multi-echo fMRI (ME-fMRI) have enabled such classification by examining the TE-dependence of each component after ICA. However, ME-fMRI needs short readouts to fit multiple echoes before signal decay, requiring sparse sampling for EPI-sequences. Here we present our cardiac-gated 4-echo spiral sequence, which allows for short echo time and readout duration, which maximizes SNR and BOLD contrast. We were able to identify and remove T1-artifacts resulting from cardiac-gating’s variable-TR, an essential aspect for applications such as spinal cord fMRI, where cardiac-gating is required to remove CSF pulsation effects.

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