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Abstract #2337

Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats

Sophie Achard1, Guillaume Becq1, Tarik Habet2, Nora Collomb2, Margaux Faucher2, Chantal Delon-Martin2, VĂ©ronique Coizet2, and Emmanuel L Barbier2

1Univ. Grenoble Alpes, CNRS, Grenoble INP, GIPSA-lab, Grenoble, France, 2Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, GIN, Grenoble, France

The Blood Oxygen Level Dependent (BOLD) signal, used in resting-state functional Magnetic Resonance Imaging (fMRI), is tighly linked to Cerebral Blood Flow (CBF). This study evaluates the impact of the CBF on the low-frequencies BOLD fluctuations and four physiological parameters during restingstate in 5 groups of rats (Wistar and Long-Evans) anesthetized with Isoflurane, Medetomidine, Etomidate and Urethane. It is shown that the CBF is not related to physiological parameters, and there exists a range of CBF values where the BOLD fluctations are sufficiently high for being used in any other analysis.

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