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Abstract #2339

Mapping drug resistant epilepsy with MREG signal coefficient of variance.

Janne Kananen1, Timo Tuovinen1, Hanna Ansakorpi2, Heta Helakari1, Niko Huotari1, Ville Raatikainen1, Aleksi Rasila1, Lauri Raitamaa1, Viola Borchardt1, Vesa Korhonen1, and Vesa Kiviniemi1

1OFNI/Radiology, Oulu University Hospital, Oulu, Finland, 2Neurology, Oulu University Hospital, Oulu, Finland

In the absence of detectable epileptiform activity, even combined EEG-fMRI scanning may fail to detect the epileptic foci. We utilize a novel measure of BOLD signal stability, the coefficient of variance (CV), with ultra-fast fMRI sequence MREG in drug resistant epilepsy (DRE). We detect a robust increase of MREG CV in patients with in white matter, brainstem and cerebellum in DRE at group level. Importantly, thresholding the CV +3 std above mean enables individual level mapping of epileptic abnormality in DRE patients.

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