Abstract #2339

Mapping drug resistant epilepsy with MREG signal coefficient of variance.

Janne Kananen¹, Timo Tuovinen¹, Hanna Ansakorpi², Heta Helakari¹, Niko Huotari¹, Ville Raatikainen¹, Aleksi Rasila¹, Lauri Raitamaa¹, Viola Borchardt¹, Vesa Korhonen¹, and Vesa Kiviniemi¹

¹OFNI/Radiology, Oulu University Hospital, Oulu, Finland, ²Neurology, Oulu University Hospital, Oulu, Finland

In the absence of detectable epileptiform activity, even combined EEG-fMRI scanning may fail to detect the epileptic foci. We utilize a novel measure of BOLD signal stability, the coefficient of variance (CV), with ultra-fast fMRI sequence MREG in drug resistant epilepsy (DRE). We detect a robust increase of MREG CV in patients with in white matter, brainstem and cerebellum in DRE at group level. Importantly, thresholding the CV +3 std above mean enables individual level mapping of epileptic abnormality in DRE patients.

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