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Abstract #2340

Resting-state fMRI reveals altered auditory and pain perception networks in patients with inflammatory bowel disease (IBD)

Faranak Heidari1, Gilaad Kaplan2, Mark Swain2, and Bradley Goodyear3

1Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, 2Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada, 3Radiology, Clinical Neurosciences, Psychiatry, The Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Inflammatory bowel disease (IBD) is a chronic and painful inflammatory-mediated disease of the gastrointestinal system. Recent animal model evidence suggests that cognitive deficits and mood changes experienced by IBD patients are not merely emotional reactions, but result from structural and functional changes in the brain. We used dual-regression analysis of resting-state fMRI data to identify alterations in functional connectivity in IBD patients compared to controls. Connectivity was altered with auditory and pain perception networks, which may help explain behavioural symptoms (hearing loss, pain) commonly experienced by IBD patients.

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