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Abstract #2341

Brain functional connectivity signatures of neuropathic pain-induced depression in a preclinical model

Meltem Karatas1,2,3,4, Muris Humo3, Laetitia Degiorgis1, Marion Sourty 1, Thomas Bienert2, CĂ©line Meillier1, Jean-Paul Armspach1, Dominik von Elverfeldt2, Ipek Yalcin3, and Laura-Adela Harsan1,2,5

1ICube, University of Strasbourg, Strasbourg, France, 2Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg im Breisgau, Germany, 3INCI, University of Strasbourg, Strasbourg, France, 4Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany, 5Hautepierre Hospital, Department of Biophysics and Nuclear Medicine, Faculty of Medicine, University Hospital Strasbourg, Strasbourg, France

Chronic pain disorders are associated with high prevalence of depression which points to a link between two pathologies; although the underlying mechanisms remain elusive. As a translational approach, preclinical MR imaging offers a unique opportunity to reliably establish causal relations between the pathological conditions and brain function in vivo. In this study, we used a mouse model of neuropathic pain to investigate affective consequences of chronic pain. We performed behavioural assessments as well as resting-state fMRI and our results show a remodelling of functional connectivity in regions belonging to default-mode network and the reward system in mice with pain-induced depression.

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