Abstract #2345

Altered Voxel-based Functional Connectivity Density of Default Mode Network in Chronic Insomnia: A resting-state fMRI study

Zhonglin Li^1,2, Enfeng Wang^1,2, Tianyi Qian³, Zhi Zou^1,2, Thomas Beck⁴, Yanrui Shen^1,2, Xiaolin Wu^1,2, Shewei Dou^1,2, Dapeng Shi^1,2, Meiyun Wang^1,2, Hongju Zhang⁵, and Yongli Li^1,2,6

¹Department of Radiology, People’s Hospital of Zhengzhou University, Zhengzhou, China, ²Department of Functional Imaging, Henan Key Laboratory for Medical Imaging of Neurological Diseases, Zhengzhou, China, ³Siemens Healthcare, Beijing, China, ⁴Siemens Healthcare, Erlangen, Germany, ⁵Department of Neurology, People’s Hospital of Zhengzhou University, Zhengzhou, China, ⁶Health Management Center, People’s Hospital of Zhengzhou University, Zhengzhou, China

This study aimed to investigate the potentially altered functional connectivity (FC) of the default-mode network (DMN) in chronic insomnia disorder (CID) patients. A voxel-based functional connectivity density (FCD) analysis method was applied to identify abnormal FC among 44 CID patients and 31 healthy controls. A seed-based FC analysis and independent component analysis were also employed and compared. CID patients showed increased FCD in the right medial temporal gyrus (MTG), including long and short distance connections. Our results suggest that hyperarousal of the DMN may be related to increased FCD of the right MTG. Furthermore, the altered connectivity within or outside the DMN may further contribute to cognitive, emotional, and memory impairment.

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