Abstract #2346

Asymmetric Functional Connectivity in Major Depressive Disorder Revealed by Ultra-high Field Resting-state fMRI

Chan-A Park¹, Enae Cheong^1,2, Youngkyu Song¹, Sungho Tak¹, Gyunggoo Cho¹, Jin-Hun Sohn², and Chaejoon Cheong^1,3

¹Bioimaging Research Team, Division of Bioconvergence Analysis, Korea Basic Science Institute, Ochang Center, Cheongju, Korea, Democratic People's Republic of, ²Department of Psychology, Brain Research Institute, Chungnam National University, Daejeon, Korea, Democratic People's Republic of, ³Department of Bio-Analytical Science, University of Science and Technology, Cheongju, Korea, Democratic People's Republic of

The purpose of the study is that the investigation of resting-state functional magnetic resonance imaging (MRI) with 7T MRI via seed-based correlation analysis is examined the significant difference of the whole-brain functional connectivity among major depressive disorder (MDD) patients and healthy subjects. The results showed that MDD had higher correlations compared with healthy group. Furthermore, MDD exhibited lateralization of connected regions, including the lateral occipital cortex, inferior temporal gyrus, angular gyrus, temporal fusiform cortex, occipital fusiform gyrus, and lingual gyrus, mainly located in the left hemisphere. These suggest that MDD is associated with disruptions in the asymmetric organization of brain.

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