The aim of this study was to investigate the effects of the well-established chronic constriction injury (CCI) model on central nociceptive processing in mice over a period of 56 days. For this purpose two behavioral tests (Hargreaves and electronic pressure-meter test [“plantar test”]) and functional MRI were combined. The ligation of the sciatic nerve induced behavioral changes indicative of a neuropathic pain state. Graph theoretical analysis of functional connectivity revealed known effects of chronic pain for the first time also for the CCI model: modifications of the sensory as well as emotional system induced by thermal but also mechanical stimulation.
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