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Abstract #2347

Changes in Brain Function induced by Chronic Neuropathic Pain in a Mouse Model of Chronic Nerve Constriction Injury

Katja Sauer1, Isabel Wank1, Silke Kreitz1, and Andreas Hess1

1University of Erlangen-Nuremberg, Institute of Pharmacology and Toxicology, Erlangen, Germany

The aim of this study was to investigate the effects of the well-established chronic constriction injury (CCI) model on central nociceptive processing in mice over a period of 56 days. For this purpose two behavioral tests (Hargreaves and electronic pressure-meter test [“plantar test”]) and functional MRI were combined. The ligation of the sciatic nerve induced behavioral changes indicative of a neuropathic pain state. Graph theoretical analysis of functional connectivity revealed known effects of chronic pain for the first time also for the CCI model: modifications of the sensory as well as emotional system induced by thermal but also mechanical stimulation.

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